DET

diethyltryptamine (also known as n,n-det or det) is a synthetic psychedelic tryptamine and a close structural analog of dmt (dimethyltryptamine). it is extremely uncommon and has little history of human usage.

chemistry

det, or n,n-diethyltryptamine, is a synthetic indole alkaloid molecule of the tryptamine class. tryptamines share a core structure comprised of a bicylic indole heterocycle attached at r₃ to an amino group via an ethyl side chain. dmt contains two ethyl groups ch₂ch₃– bound to the terminal amine r_n of its tryptamine backbone. det has many substituted analogues such as 4-ho-det (“ethocin”).

pharmacology

due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based on its structure and subjective effect similarities to other tryptamine psychedelics such as psilocin and dmt. with this in mind, det is thought to act as an 5-ht_2a partial agonist.

unlike dmt, the ethyl groups add protection against the monoamine oxidase enzyme system, allowing det to be orally active, while dmt is not.

however, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.