In 2010, 4-MMC was the fourth most popular among British clubbers, in 2018 it is 3-MMC!
it’s now used almost exclusively on the gay chemsex circuit, thanks to its chemical aphrodisiac qualities and the fact it keeps you awake and alert. So where did it come from and how did it fall so out of favour?
The active agent in mephedrone is a form of cathinone, a substance that occurs naturally in khat, the mildly stimulative root chewed all over the Horn of Africa. The exponentially stronger “substituted cathinone” molecule in mephedrone was re-synthesised in 2003 by the legendary Israeli underground chemist Dr Zee, but the explosion in drone’s popularity in the late-2000-10s was down to a different source altogether: the War on Drugs itself.
What do we know about it’s great successor, 3-MMC? I’ll wrote it all down in this comprehensive guide.
So, what is 3-MMC?
Other names are 3-methylmethcathinone and metaphedrone.
Cathinone is the principal active component in the khat plant (cathulla edullis). 3-MMC usually comes in the form of white powder or crystallized shards.
Ingestion produces powerful, fast-acting, short-lived euphoric stimulant-entactogen effects.
This appears in a significant percentage of its users.
Using too often, in excessive amounts, or extended periods of time, one will induce:
3-MMC CHEMISTRY
3-mmc is a molecule of the substituted cathinone class.
Members of the cathinone family share a amphetamine structure.
This structure consists of a phenyl ring bound to an amino (nh2) group.
An ethyl chain and an optional methyl substitution at rα facilitates this phenomenon.
Both substances comprise of ketone substitution.
This process lives on the beta carbon of the amphetamine skeleton.
This means they are β-keto-amphetamines.
3mmc has two methyl substitutions on its cathinone skeleton.
One of them exists at r3 of the phenyl ring.
The second at the nitrogen group rn.
3mmc is analogous to mephedrone, since it is identical in structure. 3-MMC PHARMACOLOGY
This results in a boost norepinephrine and dopamine neurotransmitters levels in the brain.
Mechanism of action is binding and blocking the transporter proteins.
Their job is to remove monoamines from the synaptic cleft.
This will often fail, causing dopamine and norepinephrine to accumulate within the brain.
SYNONYMS:
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