n-methyl-n-isopropyltryptamine (also known as mipt) is a lesser-known psychedelic substance of the tryptamine class that produces psychedelic effects when administered. it is structurally related to tryptamines like dmt, dipt, and met, although it is reported to produce qualitatively different effects. its effects are generally described as mild, indistinct, and highly variable between users. in contrast to many related tryptamines, it is able to be taken orally.
mipt was first synthesized and investigated by alexander shulgin and described in his book tihkal (“tryptamines i have known and loved”). in the commentary, shulgin notes that “there is almost a total lack of visual phenomena… no wave-forms, color distortion or object shape changes, and no eyes-closed imagery, unlike most n,n-disubstituted tryptamines.”
today, mipt remains relatively uncommon and is either used as a recreational or an entheogenic substance. it has been distributed online as a research chemical. very little data exists about the pharmacological properties, metabolism, and toxicity of mipt in humans, and it has little history of human usage.
mipt is the methyl analog of dipt.
like with most psychedelic tryptamines, mipt is thought to act principally as a 5-ht2a partial agonist. the psychedelic effects are believed to come from mipt’s binding efficacy at the 5-ht2a receptors.
however, the role of these interactions and how it results in the psychedelic experience continues to remain elusive.