4F-MPH

4-fluoromethylphenidate (commonly known as 4f-mph) is a novel synthetic stimulant of the substituted phenethylamine and piperidine classes that produces long-lasting euphoriant, and stimulating effects when administered. it is a closely related structural analog of the commonly prescribed adhd drug methylphenidate (known by the brand-names ritalin and concerta).

the two substances are believed to have very similar pharmacological mechanisms as monoamine reuptake inhibitors but have been reported to display distinctive subjective effects, with 4f-mph being considered significantly more euphoric and recreational. anecdotal reports suggest that it is considerably more potent with fewer uncomfortable side effects such as anxiety, muscle spasms and compulsive redosing. this perhaps owes to the fact that it has been shown to act as a higher efficiency dopamine reuptake inhibitor than the parent compound methylphenidate.

4f-mph has an extremely short history of recreational use and has yet to be documented being sold on the streets. it was initially developed as a replacement for ethylphenidate which became illegal in the united kingdom on april 2015 following a temporary blanket ban. shortly after, it recently became made available for sale on the online gray market as a research chemical for global distribution.

due to its potent, long-lasting stimulant effect, likely habit-forming properties as well as unknown toxicity profile, it is strongly recommended that one use proper harm reduction practices if choosing to use this substance.

chemistry

4f-mph is a synthetic molecule of the substituted phenethylamine and piperidine classes, and a fluorinated analog of methylphenidate. it contains a phenethylamine core featuring a phenyl ring bound to an amino -nh2 group through an ethyl chain. it is structurally similar to amphetamine, featuring a substitution at rα which is incorporated into a piperidine ring ending at the terminal amine of the phenethylamine chain. additionally, it contains a methyl acetate bound to r2 or its structure. 4f-mph is structurally identical to methylphenidate with the exception of a single fluorine atom bound to the four position on the phenethylamine core.

with respect to nomenclature, the methyl- in methylphenidate regards the side chain of one carbon atom, while phen- indicates the phenyl ring. id- is contracted from a piperidine ring, and -ate indicates the acetate group containing the oxygen atoms. like its parent molecule, 4f-mph is a chiral compound, presumably produced as a racemic mixture.

of note is the scientific finding that amphetamine analogs containing fluorine, chlorine, bromine and methyl groups are typically stronger than those without.

pharmacology

4f-mph is thought to act primarily as a dopamine reuptake inhibitor, meaning it effectively boosts the levels of dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins that normally clear these monoamines from the synaptic cleft. this allows dopamine to accumulate within the reward pathways in the brain, resulting in stimulating and euphoric effects.