4-HO-DPT

4-ho-dpt (also known as 4-hydroxy-dipropyltryptamine and sometimes referred to as procin) is a psychedelic substance of the tryptamine class. alexander shulgin first synthesized 4-ho-dpt and documented it in his book tihkal (tryptamines i have known and loved). it is the 4-hydroxyl analog of dpt.

today it is either used recreationally or as an entheogenic compound and is typically acquired through the use of online research chemical vendors. due to the difficulty of its synthesis, it remains relatively uncommon even for a substituted tryptamine and has very little history of human usage.

chemistry

4-ho-dpt, or 4-hydroxy-n,n-dipropyltryptamine, is a synthetic indole molecule of the tryptamine class. tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at r₃ to an amino group via an ethyl side chain. 4-ho-dpt is substituted at r₄ of its indole heterocycle with a hydroxyl functional group oh−. it also contains two propyl chains bound to the terminal amine r_n of its tryptamine backbone (dpt).

4-ho-dpt is a 4-hydroxy analog of 4-aco-dpt and the n-substituted dipropyl homolog of psilocin (4-ho-dmt).

pharmacology

like with most psychedelic tryptamines, 4-ho-dpt is thought to act principally as a 5-ht_2a partial agonist. the psychedelic effects are believed to come from 4-ho-dpt’s binding efficacy at the 5-ht_2a receptors. however, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.