4-AcO-MiPT

4-acetoxy-n-methyl-n-isopropyltryptamine (abbreviated 4-aco-mipt and also known as mipracetin) is a synthetic psychedelic tryptamine. it is the acetylated form of 4-ho-mipt (also known as miprocin) and is a higher homolog of 4-aco-dmt, 4-aco-met and 4-aco-det. these substances are commonly hypothesized to act primarily as prodrugs for their respective hydroxylated counterparts (e.g. 4-ho-dmt, 4-ho-met and 4-ho-det), although there is on-going debate as to whether they possess their own innate activity.

there is very little information on the human pharmacology or toxicity of 4-aco-mipt, although analytical methods have been developed for its detection. today it is either used recreationally or as an entheogenic substance and is typically acquired through the use of online research chemical vendors. it remains relatively uncommon and has very little history of human usage.

chemistry

4-aco-mipt, or 4-acetoxy-n-isopropyl-n-methyltryptamine, is a synthetic indole alkaloid molecule of the tryptamine class. tryptamines share a core structure comprised of a bicylic indole heterocycle attached at r₃ to an amino group via an ethyl side chain. 4-aco-mipt is substituted at r₄ of its indole heterocycle with an acetoxy (aco) functional group ch₃coo−. it also contains isopropyl and methyl chains bound to the terminal amine r_n of its tryptamine backbone (mipt).

4-aco-mipt is the n-substituted methisopropyl homologue of 4-ho-dmt (psilocin). 4-aco-mipt is the acetate ester analog of mipt and the n-substituted methisopropyl analog of 4-aco-dmt.

pharmacology

like with most psychedelic tryptamines, 4-aco-mipt is thought to act principally as a 5-ht_2a partial agonist. the psychedelic effects are believed to come from 4-aco-mipt’s binding efficacy at the 5-ht_2a receptors.

however, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.