25C-NBOH

25c-nboh (also known as 2c-c-nboh and nboh-2cc) is novel synthetic psychedelic substance of the phenethylamine chemical class that produces an array of visually-dominant and stimulating psychedelic effects when administered. it is a closely related analog of 25b-nbome and is reported to share most of its properties with the exception of a moderately reduced potency and a shorter duration.

the name 25c-nboh, which is short-hand for 2c-c-nboh, is a derivative of the phenethylamine psychedelic 2c-c. it was first synthesized and documented in 2011 by martin hansen at the university of copenhagen.

it is worth noting that compounds of the nboh family are not orally active and should be administered sublingually by placing and holding it into one’s mouth and allowing it to absorb over a period of 15-25 minutes.

extremely little is known about the pharmacological properties, metabolism, and toxicity of 25c-nboh in humans. it has no history of human use before being sold online as a designer drug in 2011. it is closely related to members of the 25x-nbome series, which have been associated with many hospitalizations and deaths. anecdotal reports suggest that this substance may be difficult to use safely due to its highly sensitive dose-response and unpredictable effects.

chemistry

25c-nboh or 2c-c-nboh, is a serotonergic n-benzyl derivative of the substituted phenethylamine psychedelic known as 2c-c. 25c-nboh is a substituted phenethylamine with methoxy groups ch₃o- attached to carbons r₂ and r₅ as well as an bromine atom attached to carbon r₄. it differs from 2c-c structurally through a substitution on the amine (nh₂) with a 2-hydroxybenzyl (boh) group. 25c-nboh shares this 2-hydroxybenzyl substitution with other chemicals of the nboh family. this nboh addition is comprised of a hydroxy ether oh- bound to a benzene ring at r₂.

pharmacology

25c-nboh has efficacy at the 5-ht_2a receptor where it acts as a potent agonist.

this compound is pharmacologically unique when compared to other psychedelics due to the unusually high selectivity it displays for various serotonin receptors. it is notable as one of the most selective agonist ligands for the 5-ht_2a receptor with a pec₅₀ value of 9.43

it acts as a potent serotonin receptor agonist with similar affinity to the better-known compound 25c-nbome at 5-ht_2a and 5-ht_2c receptors with pkis values of 9.4 and 7.8, respectively.

however, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.