25B-NBOMe

25b-nbome (also known as cimbi-36 and 2c-b-nbome) is novel synthetic psychedelic substance of the phenethylamine chemical class. it produces an array of visually-dominant and stimulating psychedelic effects when administered.

the name 25b-nbome, which short-hand for 2c-b-nbome, is a derivative of the phenethylamine psychedelic 2c-b. it was discovered in 2004 by ralf heim at the free university of berlin. it acts as a potent partial agonist for the 5-ht_2a receptor. it has been used in clinical trials with an evaluation dose for safety consideration to humans of only 1 microgram. such a dose was determined to be only 1/300th the dose expected to be hallucinogenic to humans and that recreational use would greatly exceed doses determined to be safe to humans.

anecdotal reports from users suggest 25b-nbome to be an active hallucinogen at a dose of as little as 250–500 µg, making it a similar potency to other phenethylamine derived hallucinogens such as bromo-dragonfly. it is worth noting that compounds of the nbome class are not orally active and should therefore be taken sublingually by placing the substance into one’s mouth and allowing it to slowly absorb over a period of 15-30 minutes.

this substance had no history of human use before being sold online as a designer drug in 2010. extremely little is known about the pharmacological properties, metabolism, and toxicity of 25b-nbome in humans, and numerous members of the 25x-nbome series have been associated with hospitalizations and deaths. along with its highly sensitive dose-response and unpredictable effects, many reports also suggest that this substance may be overly difficult to use safely. therefore it is highly advised to approach this poorly understood, potentially deadly psychedelic substance with the proper amount of precaution and harm reduction practices if choosing to use it.

chemistry

25b-nbome or 2c-b-nbome is a serotonergic n-benzyl derivative of the substituted phenethylamine psychedelic known as 2c-b. 25b-nbome is a substituted phenethylamine with methoxy groups ch₃o- attached to carbons r₂ and r₅ as well as a bromine atom attached to carbon r₄. it differs from 2c-b structurally through a substitution on the amine (nh2) with a 2-methoxybenzyl (bome) group. 25b-nbome shares this 2-methoxybenzyl substitution with other chemicals of the nbome family. this nbome addition contains a methoxy ether ch₃o- bound to a benzene ring at r₂.

pharmacology

25b-nbome has efficacy at the 5-ht_2a receptor where it acts as a potent partial agonist. however, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.