1P-ETH-LAD

1-propionyl-6-ethyl-6-nor-lysergic acid diethyamide (also known as 1p-eth-lad) is a semisynthetic psychedelic substance of the lysergamide chemical class. it is a designer drug analog and suspected prodrug to eth-lad, which shares a close structural relationship with lsd and 1p-lsd. anecdotal reports suggest that this compound produces largely similar psychedelic effects comparable to eth-lad or al-lad.

like its parent compound eth-lad, this compound has been reported to be moderately to significantly more potent than lsd itself. it has also been reported as being subtly different in effect to lsd and is often described as being more visual and synaesthetic, with a deeper, less emotionally-charged headspace analogous to that of psychedelics like 2c-e or dpt. it has also been reported to be more likely to induce undesirable effects like anxiety, thought loops in addition to pronounced nausea and other discomforting physical effects it displays relative to other lysergamides.

very little data exists about the pharmacological properties, metabolism, and toxicity of 1p-eth-lad, and it has little history of human usage before january 2016. it has recently become commonly marketed alongside other designer psychedelics such as 1p-lsd and eth-lad as a legal alternative to lsd and is commercially distributed through online research chemical vendors.

chemistry

1p-eth-lad, or 1-propionyl-6-ethyl-6-nor-lysergic acid diethylamide, is a semi-synthetic alkaloid of the lysergamide family. 1p-eth-lad is a structural analog of lysergic acid, with an n, n-diethylamide functional group bound to r_n of the chemical structure. this core polycyclic structure is an ergoline derivative and has tryptamine and phenethylamine groups embedded within it.

1p-eth-lad’s structure contains a bicyclic hexahydro indole fused to a bicyclic quinoline group (nor-lysergic acid). 1p-eth-lad does not contain a methyl group substituted at r₆ of its nor-lysergic acid skeleton; the nor- prefix represents this. instead, 1p-eth-lad is substituted at r₆ with an ethyl group and at r₁ with a propionyl group. at carbon 8 of the quinoline, an n, n-diethyl carboxamide is bound.

1p-eth-lad is a chiral compound with two stereocenters at r₅ and r₈. 1p-eth-lad, also called (+)-d-1p-eth-lad, has an absolute configuration of (5r, 8r). the three other stereoisomers of 1p-eth-lad have not been shown to possess psychoactive properties.

pharmacology

this compound likely acts as a 5-ht_2a partial agonist. the psychedelic effects are believed to come from 1p-eth-lad’s efficacy at the 5-ht_2a receptors. however, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

1p-eth-lad shares many common traits with its parent compound lsd; it appears to be roughly equal in potency as well as similar in mechanism although the progression and duration of effects are compressed (while remaining qualitatively less intense and more manageable) due to suspected differences in how it is metabolized. research has shown formation of eth-lad from 1p-eth-lad incubated in human serum, suggesting that it functions as a pro-drug.