|Substitutive name||1-Butyryl-d-lysergic acid diethylamide|
1-butanoyl-d-lysergic acid diethylamide (also known as 1b-lsd) is a substance with psychedelic characteristics and is member of the lysergamide class.
The substance is is closely related to lsd and 1p-lsd and is reported to produce near-identical effects.
little is known about the pharmacology of 1b-lsd, but it likely produces its psychedelic effects by acting on serotonin receptors in the brain.
The original synthesis date of 1b-lsd is unknown. unlike most research chemicals, 1b-lsd has no prior record in the scientific literature, although reports use surfaced in 2018 following its appearance on the online research chemical market.
user reports indicate that the subjective effects of this compound are extremely similar to those of 1p-lsd. 1b-lsd is theorized to act as a prodrug for lsd.
the similarities in chemical structure between 1b-lsd and lsd predicts a near-identical effect profile, likely differing mainly in its rate of absorption and duration. characteristics effects include geometric visual hallucinations, time distortion, enhanced introspection, and ego loss. its classical psychedelic effects and favorable tolerability has led it to become popular among novel psychoactive substance users who use it interchangeably with lsd.
very little data exists about the pharmacological properties, metabolism, and toxicity of 1b-lsd. it is presumed to have a similar toxicity and risk profile as lsd, although no evidence currently exists to support this. it is highly advised to use harm reduction practices if using this substance.
history and culture
1b-lsd first appeared on the online research chemical market in september 2018.
it is unknown who first synthesized 1b-lsd, as the substance does not appear in any academic literature pre-dating its arrival on the research chemical market.
interestingly, the future usage of 1-akylated lysergamide derivatives as a means to bypass controlled substance laws banning lsd as a precursor was foreseen in a dea report from 1988:
the tetracyclic ergoline is characteristic of the chemical structure of ergot alkaloids. in contrast to lsd, 1b-lsd has an additional n1-butyryl group. chemical modifications in the n1 position are among the most frequently performed changes in the ergoline system, as the indole nitrogen is easily accessible for alkylations, acylations, mannich reactions and michael additions.
based on its structural similarity to lsd, this compound likely acts as a partial agonist at the 5-ht2a receptor.
the psychedelic effects are thought to primarily come from its efficacy at the 5-ht2a receptors distributed throughout the brain. 1b-lsd also likely displays binding activity at a wide range of monoamine receptors, such as those for dopamine and norepinephrine. however, there is currently no data to support these claims.